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The effects of ablations in the central nervous system on arrhythmias induced by coronary occlusion in the rat
Author(s) -
Curtis M.J.,
Macleod B.A.,
Walker M.J.A.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08943.x
Subject(s) - medicine , occlusion , coronary occlusion , platelet , coronary artery occlusion , cardiology , central nervous system , anesthesia
1 The role of the central nervous system (CNS) in arrhythmogenesis in the 4 h period following occlusion of a coronary artery was investigated in rats by use of CNS ablations and other procedures. 2 Ablations in the CNS included pithing, spinalization and decerebration combined with acute and chronic surgical preparation and noradrenaline/adrenaline infusions. 3 All procedures involving acute surgery reduced the incidence and severity of the arrhythmias induced by occlusion. Such reductions were most marked in the second (0.5‐4 h post‐occlusion) arrhythmic period. 4 The observed reductions in arrhythmias could not be explained in terms of involvement of the CNS or adrenoceptor activation. 5 When circulating leucocytes, platelets and serum potassium were measured in a group of pithed rats before and after occlusion, reduced levels (20–50%) of both leucocytes and platelets occurred while serum potassium levels rose by 50–100%. 6 Arrhythmias following coronary occlusion may depend in part on factors in the blood such as leucocytes, platelets and serum potassium and these factors may be altered by acute surgery.