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Responses of human skin to intradermal injection of leukotrienes C 4 , D 4 and B 4
Author(s) -
Camp R.D.R.,
Coutts A.A.,
GreavesM M.W.,
Kay A.B.,
Walport M.J.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10721.x
Subject(s) - prostaglandin e2 , leukotriene , erythema , eicosanoid , prostaglandin , leukotriene b4 , inflammation , leukotriene d4 , prostaglandin e , intradermal injection , medicine , immunology , pathology , endocrinology , chemistry , arachidonic acid , biochemistry , enzyme , asthma
1 The ability of intradermally injected leukotrienes C 4 (LTC 4 ), LTD 4 and LTB 4 to produce inflammatory changes in human skin alone and in combination with prostaglandin E 2 (PGE 2 ) has been investigated. 2 LTC 4 and D 4 (0.012–0.38 nmol) caused dose‐related erythema and wealing. No evidence of synergism between PGE 2 and LTC 4 or LTD 4 was detected, although only single dose combinations were studied. 3 LTB 4 (0.15–1.5 nmol) caused areas of induration which persisted for more than 4 h and which showed perivascular neutrophil infiltrates on histological examination. Only slight synergism between PGE 2 and LTB 4 was found. 4 It was concluded that these pro‐inflammatory properties of LTC 4 , LTD 4 and LTB 4 are consistent with their proposed roles as mediators of inflammation in the skin and other tissues.