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UNEXPECTED ANTAGONISM IN THE RAT VAS DEFERENS BY BENZOMORPHANS WHICH ARE AGONISTS IN OTHER PHARMACOLOGICAL TESTS
Author(s) -
GILLAN MAUREEN G.C.,
KOSTERLITZ HANS W.,
MAGNAN JACQUES
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09098.x
Subject(s) - vas deferens , agonist , antagonism , ileum , medicine , endocrinology , pharmacology , chemistry , receptor
The benzomorphans, ethylketazocine, bremazocine and MR 2034 are pure agonists in the guinea‐pig ileum and mouse vas deferens but are competitive antagonists without agonist activity in the rat vas deferens.