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SUBSENSITIVITY TO CHOLINOCEPTOR STIMULATION OF THE HUMAN IRIS SPHINCTER in situ FOLLOWING ACUTE AND CHRONIC ADMINISTRATION OF CHOLINOMIMETIC MIOTIC DRUGS
Author(s) -
SMITH SHIRLEY A.,
SMITH S.E.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07042.x
Subject(s) - miosis , pilocarpine , atropine , mydriasis , medicine , physostigmine , stimulation , pupil , iris (biosensor) , anesthesia , glaucoma , brimonidine , muscarinic acetylcholine receptor , reflex , anticholinergic agents , anticholinergic , acetylcholine , ophthalmology , pharmacology , biology , epilepsy , computer security , neuroscience , psychiatry , biometrics , computer science , receptor
1 Maximal pupillary miosis was obtained with single topical applications of 4 cholinomimetic drugs in therapeutic concentrations to normal human subjects. 2 When the pupil had recovered from the miosis, there remained a reduced light reflex response of 22.7% at 24 h after aceclidine, 18.0% at 31 h after pilocarpine, 10.3% at 48 h after physostigmine and 4.9% at 7 h after arecoline. 3 This reduced sensitivity to light was accompanied by an overshoot of the resting pupil diameter and, after aceclidine miosis, a reduced response to a second application of miotic. 4 Similar findings were observed in glaucoma patients following withdrawal of chronic pilocarpine therapy. 5 It is suggested that the slowly reversible after‐effects of acute and chronic administration of cholinomimetic miotics can be explained by desensitization of iris sphincter cholinoceptors.