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EFFECTS OF BENZOCTAMINE AND CHLORDIAZEPOXIDE ON TURNOVER AND UPTAKE OF 5‐HYDROXYTRYPTAMINE IN THE BRAIN
Author(s) -
LIPPMANN W.,
PUGSLEY T.A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09676.x
Subject(s) - chlordiazepoxide , neuroscience , chemistry , pharmacology , medicine , psychology , diazepam
1 Benzoctamine, a new psychoactive drug, known to exert in man an anti‐anxiety effect resembling that of chlordiazepoxide, decreased the disappearance of intraventricularly‐injected [ 14 C]‐5‐hydroxytryptamine (5‐HT) from rat brain, as did chlordiazepoxide. 2 Both drugs partially inhibited the α‐ethyl‐3‐hydroxy‐4‐methylphenylethylamine‐induced depletion of rat brain 5‐HT. 3 It is concluded that benzoctamine, like chlordiazepoxide, decreases 5‐HT turnover in the brain and that this action may play a role in the anti‐anxiety effect of these drugs observed in man.