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ANTAGONISM OF THE SPINAL ACTION OF DIAZEPAM BY SEMICARBAZIDE
Author(s) -
BAN.R.,
JABBUR S.J.,
SAADÉ N.E.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09637.x
Subject(s) - semicarbazide , diazepam , antagonism , cats , pharmacology , reflex , chemistry , anesthesia , medicine , biochemistry , receptor , organic chemistry
In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2–4.5 h prior to the administration of diazepam (1–4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered 1 h later. The possibility of a link between diazepam and spinal γ‐aminobutyric acid is suggested and discussed.