Effects of vinblastine on catecholamine‐biosynthetic enzymes in heart, sympathetic ganglion and adrenal glands of rats | Zendy

HANBAUER I. | Zendy; KOPIN I. J. | Zendy; MAENGWYNDAVIES GERTRUDE D. | Zendy; THOA N. B. | Zendy; WEISE VIRGINIA K. | Zendy

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Effects of vinblastine on catecholamine‐biosynthetic enzymes in heart, sympathetic ganglion and adrenal glands of rats

Author(s) -

HANBAUER I.,

KOPIN I. J.,

MAENGWYNDAVIES GERTRUDE D.,

THOA N. B.,

WEISE VIRGINIA K.

Publication year - 1973

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/j.1476-5381.1973.tb08227.x

Subject(s) - medicine , endocrinology , superior cervical ganglion , adrenal medulla , adrenal gland , catecholamine , ganglion , tyrosine hydroxylase , vinblastine , cervical ganglia , denervation , dopamine , biology , anatomy , chemotherapy

Summary1 The effect of vinblastine on the activities of dopamine‐β‐hydroxylase (DBH) in heart, superior cervical ganglion and adrenal glands of rats and tyrosine hydroxylase (TH) and phenylethanolamine‐ N ‐methyl transferase (PNMT) in adrenal glands was examined. 2 In the superior cervical ganglion and heart, DBH activity decreased within hours, reached a minimum in 3 to 5 days and slowly returned towards normal over the next 2 weeks. 3 There was an increase in the activities of TH, DBH and PNMT in adrenal glands which was prevented by adrenal denervation. 4 When the same total dose of vinblastine was administered subdivided over a period of 5 days, enzyme activities in heart, superior cervical ganglion or adrenal glands remained unchanged.

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