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Tolerance to the hypothermic effects of Δ9‐tetrahydrocannabinol as a function of age in the chicken
Author(s) -
ABEL E. L.,
McMILLAN D. E.,
HARRIS L. S.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08176.x
Subject(s) - δ9 tetrahydrocannabinol , hypothermia , delta 9 tetrahydrocannabinol , drug tolerance , biology , physiology , anesthesia , medicine , pharmacology , cannabinoid , receptor
Summary1 (—)‐Δ 9 ‐Tetrahydrocannabinol was administered to chicks ( Gallus domesticus ) of various ages and body temperature and tolerance to the hypothermic effects of the drug were examined as a function of age. 2 The hypothermic effects were found to be greater in neonatal than older animals and likewise tolerance took longer to develop in younger chicks. 3 The rate of tolerance development, however, could be increased in the neonate by preadministration of a high dose of the drug.