Premium
Actions of levodopa on the blood pressure of conscious rabbits
Author(s) -
CALNE D. B.,
REID J. L.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb06905.x
Subject(s) - levodopa , blood pressure , medicine , anesthesia , neuroscience , psychology , parkinson's disease , disease
Summary1 . In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg. 2 . After inhibition of monoamine oxidase, levodopa induces a sustained pressor response. 3 . This response can be blocked by inhibition of extracerebral decarboxylase. 4 . Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.