Premium
Comparison of the effects of propranolol and MJ 1999 on cardiac β‐adrenoceptors in man
Author(s) -
EKUE J. M. KOFI,
LOWE D. C.,
SHANKS R. G.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10596.x
Subject(s) - propranolol , medicine , endocrinology , chemistry
Summary1 . Propranolol, a β‐adrenoceptor blocking drug with local anaesthetic and a direct myocardial depressant action, and MJ 1999, a β‐adrenoceptor blocking drug which has no local anaesthetic or intrinsic sympathomimetic action, were compared for β‐adrenoceptor blocking activity in man. 2 . Propranolol was 2·67 times more active than MJ 1999 in reducing by 50% the tachycardia produced by the intravenous infusion of isoprenaline in healthy volunteers. 3 . Propranolol and MJ 1999 intravenously both reduced resting heart rate in the standing position and an exercise tachycardia, but there was no qualitative or quantitative difference between them. 4 . On oral administration, both propranolol and MJ 1999 reduced resting heart rate and an exercise induced tachycardia; propranolol was only slightly more active than MJ 1999. 5 . In patients with thyrotoxicosis propranolol was about twice as active as MJ 1999 in reducing the heart rate.