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Anti‐inflammatory activity of the steroid alkaloid glycoside, tomatine
Author(s) -
FILDERMAN R. B.,
KOVACS B. A.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08514.x
Subject(s) - carrageenan , alkaloid , aglycone , chemistry , pharmacology , glycoside , saline , intraperitoneal injection , biochemistry , medicine , endocrinology , stereochemistry
1 . Tomatine, isolated from extracts of crown gall‐infected tomato plants or obtained commercially, was tested for anti‐inflammatory activity using three different methods. 2 . Tomatine administered to intact rats intramuscularly in a dose range of 1–10 mg/kg or orally in doses of 15–30 mg/kg exerted a significant dose dependent inhibition of carrageenan induced paw oedema. The inhibitory effect of tomatine when given in a dose of 10 mg/kg intramuscularly to intact rats lasted more than 24 hr. 3 . In adrenalectomized rats significant dose‐related inhibition of paw oedema was obtained with tomatine and the inhibition at each dose level (0·5–10 mg/kg) was found to be greater than that found in intact animals. 4 . Tomatine administered subcutaneously to intact rats daily for 7 days in doses of 5 or 10 mg/kg exerted a significant, dose dependent inhibition of granulation tissue formation induced by the subcutaneous implantation of carrageenan impregnated cotton pellets. 5 . Tomatine administered to intact mice in a dose of 10 mg/kg subcutaneously 1 hr before the intraperitoneal injection of acidified saline and intravenous pontamine sky blue significantly decreased the leakage of the protein bound dye into the peritoneal cavity. 6 . Tomatidine, the aglycone of tomatine, was not effective at dose levels of 10–20 mg/kg in any of the three tests.