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ANTI‐EMETIC ACTIVITY OF PHENOTHIAZINES IN RELATION TO THEIR CHEMICAL STRUCTURE
Author(s) -
BHARGAVA K. P.,
CHANDRA OM
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb02011.x
Subject(s) - relation (database) , neuroscience , pharmacology , medicine , psychology , computer science , database
Twelve phenothiazine derivatives have been studied for anti‐emetic potency in dogs against emesis induced by apomorphine. The PD 50 S of all the compounds were determined and the activities compared with chlorpromazine hydrochloride as standard. Thioproperazine methanesulphonate was 300 times more active than chlorpromazine hydrochloride and twice as active as perphenazine sodium citrate. The anti‐emetic activity of the compounds has been correlated with their chemical structure.