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THE EFFECT OF RESERPINE ON THE PRESSOR RESPONSE TO INJECTION OF 2‐HALOGENOETHYLAMINE
Author(s) -
GRAHAM J. D. P.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb00299.x
Subject(s) - reserpine , hexamethonium , adrenalectomy , antagonist , chemistry , pressor response , blood pressure , medicine , endocrinology , norepinephrine , pharmacology , acetylcholine , receptor , dopamine , heart rate
Dibenamine‐like compounds sometimes caused an increase in blood pressure when injected intravenously in mammals. This response varied with species, with the preparation, and with the structure of the compound. The response became smaller after repeated injections. In spinal atropinized rats injected with hexamethonium 5 mg/kg this pressor effect produced by injection of the adrenaline antagonist, compound AT3 [ethylfluoren‐9‐yl(2‐iodoethyl)amine hydriodide], was reduced by prior treatment for five days with 1 mg/kg reserpine. Acute adrenalectomy also reduced this effect of the adrenaline antagonist; reserpine plus adrenalectomy abolished it. Subsequent injection of adrenaline and noradrenaline restored it.