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THE FATE OF OXYTOCIN IN MALE AND FEMALE RATS
Author(s) -
GINSBURG M.,
SMITH M. W.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00252.x
Subject(s) - oxytocin , splanchnic , endocrinology , medicine , antidiuretic , hormone , extracellular fluid , blood volume , lactation , splanchnic circulation , kidney , biology , extracellular , blood flow , pregnancy , genetics , microbiology and biotechnology
A method for quantitative extraction of oxytocin from blood is described. The disappearance of injected oxytocin from the circulation in rats was shown to depend upon its uptake in the kidneys and in organs of the splanchnic vascular area. In lactating rats there was uptake by an additional organ or tissue, probably the mammary gland. In animals without kidneys or lactating mammary glands and with no circulation in the splanchnic area oxytocin was distributed into a volume greater than the extracellular fluid volume, and after equilibration the concentration in plasma did not change significantly. During severe haemorrhage increased amounts of antidiuretic activity were detected in blood when there was no significant increase in oxytocic activity.