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AN INHIBITORY EFFECT OF ACETYLCHOLINE ON THE RESPONSE OF THE GUINEA‐PIG ILEUM TO HISTAMINE
Author(s) -
DALE M. MAUREEN
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00183.x
Subject(s) - histamine , acetylcholine , atropine , ileum , guinea pig , inhibitory postsynaptic potential , contraction (grammar) , chemistry , endocrinology , medicine , muscle contraction , pharmacology , biology
If small doses of histamine are alternated with small doses of acetylcholine on the isolated guinea‐pig ileum in Tyrode solution, the response to histamine tends to diminish and may disappear. When the response to the small doses of histamine has disappeared, a contraction may be elicited by larger doses. The diminution is reversible, the response returning if the preparation is left unstimulated by drugs for varying periods of time. This phenomenon also occurs when the loops are suspended in Tyrode solution containing cocaine or atropine.
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