Open AccessThe CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease
Author(s) -
Yu Lei,
Shulman Joshua M.,
Chibnik Lori,
Leurgans Sue,
Schneider Julie A.,
De Jager Philip L.,
Bennett David A.
Publication year - 2012
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2011.00777.x
Subject(s) - dementia , cognitive decline , alzheimer's disease , biology , polymorphism (computer science) , cholesterylester transfer protein , disease , medicine , cohort , oncology , cholesterol , endocrinology , allele , genetics , gene , lipoprotein
Summary The cholesteryl ester transfer protein ( CETP ) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late‐onset Alzheimer’s disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinical–pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry. Our results suggest that the CETP I405V polymorphism was associated with a faster rather than a slower rate of decline in cognition over time, and an increased risk of incident AD. This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy.