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Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin–nicotinamide‐induced type 2 diabetes
Author(s) -
Pari Leelavinothan,
Murugan Pidaran
Publication year - 2007
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00542.x
Subject(s) - curcumin , hydroxyproline , chemistry , glycation , antioxidant , streptozotocin , oral administration , streptozocin , nicotinamide , pharmacology , diabetes mellitus , biochemistry , endocrinology , medicine , enzyme , receptor
Abstract Changes in the structural and functional properties of collagen caused by advanced glycation might be of importance for the etiology of late‐stage complications in diabetics. Curcumin is the most active component of turmeric. It is believed that curcumin is a potent antioxidant and anti‐inflammatory agent. Tetrahydrocurcumin (THC) is one of the major metabolites of curcumin, exhibiting many of the same physiological and pharmacological activities of curcumin and in some systems may exert greater antioxidant activity than curcumin. In diabetic rats, hydroxyproline and collagen content as well as its degree of cross‐linking were increased, as shown by increased extent of glycation, collagen‐linked fluorescence, neutral salt collagen, and decreased acid and pepsin solubility. Administration of THC for 45 days to diabetic rats significantly reduced the accumulation and cross‐linking of collagen. The effects of THC were comparable with those of curcumin. In conclusion, administration of THC had a positive influence on the content of collagen and its properties in streptozotocin‐ and nicotinamide‐induced diabetic rats. THC was found to be more effective than curcumin.