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Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations
Author(s) -
Dupuis Antoine,
Pariat Claudine,
Courtois Philippe,
Couet William,
Bouquet Serge
Publication year - 2000
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2000.tb00406.x
Subject(s) - meropenem , imipenem , cerebrospinal fluid , medicine , anesthesia , convulsion , epilepsy , pharmacology , antibiotics , microbiology and biotechnology , biology , psychiatry , antibiotic resistance
— Imipenem and meropenem CSF diffusion was comparable in DBA/2 mice but only imipenem induced convulsions, not related to CSF concentration.