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Effect of zolpidem during sleep on ventilation and cardiovascular variables in normal subjects
Author(s) -
Cann C Crowe Mc,
QueraSalva MA,
Boudet J.,
Frisk M.,
Barthouil P.,
Borderies P.,
Meyer P.
Publication year - 1993
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1993.tb00244.x
Subject(s) - zolpidem , placebo , heart rate , blood pressure , medicine , anesthesia , respiratory disturbance index , ventilation (architecture) , diastole , cardiology , polysomnography , insomnia , apnea , pharmacology , mechanical engineering , alternative medicine , pathology , engineering
Summary— A double‐blind study comparing the effect of zolpidem 10 mg, and placebo, on sleep architecture, nocturnal ventilation, cardiovascular parameters (heart rate, systolic, diastolic and mean blood pressures) was carried out. Ten healthy middle‐aged males took part in the study. No significant differences were found between zolpidem and placebo in relation to sleep architecture. Mean respiratory disturbance index (RDI) and SaO 2 values (mean SaO 2 , time spent with SaO 2 < 90%) were similar under both conditions. The diastolic and mean blood pressure readings taken from REM periods which occurred during the first third of the night were significantly higher with zolpidem. No changes in systolic blood pressure or heart rate were found with zolpidem in comparison to placebo.