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Antimicrobial properties of delmopinol against oral bacteria
Author(s) -
Elworthy A.J.,
Wade W.G.
Publication year - 1995
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1995.tb00425.x
Subject(s) - antimicrobial , bacteria , agar dilution , minimum inhibitory concentration , chemistry , chlorhexidine , morpholine , agar , microbiology and biotechnology , minimum bactericidal concentration , dilution , biology , medicine , genetics , dentistry , medicinal chemistry , physics , thermodynamics
Antimicrobial properties of the morpholine derivative delmopinol hydrochloride were investigated in vitro . Minimum inhibitory concentrations were measured for a range of oral bacteria by broth and agar dilution techniques and minimum bactericidal concentrations were measured in broth. The rate of kill was investigated by determination and analysis of kill curves. The results indicated that delmopinol is a relatively weak antimicrobial in comparison with chlorhexidine. However, it may selectively affect certain species of oral bacteria which are of importance in plaque formation.