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Carbon‐phosphorus lyase activity—a novel mechanism of bacterial resistance to the phosphonic acid antibiotics?
Author(s) -
Quinn J.P.
Publication year - 1989
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1989.tb00236.x
Subject(s) - bacillus megaterium , phosphonate , fosfomycin , phosphorus , bacteria , microbiology and biotechnology , pseudomonas , pseudomonadaceae , antibiotics , pseudomonadales , chemistry , biology , bacillus subtilis , biochemistry , organic chemistry , genetics
Strains of Pseudomonas and of Bacillus megaterium , originally isolated from soil by their ability to cleave the carbon‐phosphorus bond of the phosphonate herbicide glyphosate, were not only resistant to the broad‐spectrum phosphonate antibiotics alafosfalin and fosfomycin at concentrations in excess of 2 mmol/1 but could also utilize each as sole phosphorus source. The extent to which their resistance is dependent upon antibiotic detoxification through C‐P lyase activity is unclear.