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Effects of the monomeric, oligomeric, and fibrillar Aβ 42 peptides on the proliferation and differentiation of adult neural stem cells from subventricular zone
Author(s) -
Heo Chaejeong,
Chang KeunA,
Choi Hee Soon,
Kim HyeSun,
Kim Seonghan,
Liew Hyunjeong,
Kim Jeong a,
Yu Eunah,
Ma Jie,
Suh YooHun
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04499.x
Subject(s) - neural stem cell , neurodegeneration , neurosphere , subventricular zone , monomer , microbiology and biotechnology , chemistry , biology , amyloid (mycology) , stem cell , cellular differentiation , biochemistry , adult stem cell , pathology , medicine , disease , gene , organic chemistry , polymer , inorganic chemistry
The incidence of amyloid plaques, composed mainly of β‐amyloid peptides (Aβ), does not correlate well with the severity of neurodegeneration in patients with Alzheimer’s disease (AD). The effects of Aβ 42 on neurons or neural stem cells (NSCs) in terms of the aggregated form remain controversial. We prepared three forms of oligomeric, fibrillar, and monomeric Aβ 42 peptides and investigated their effects on the proliferation and neural differentiation of adult NSCs, according to the degree of aggregation or concentration. A low micromolar concentration (1 μmol/L) of oligomeric Aβ 42 increased the proliferation of adult NSCs remarkably in a neurosphere assay. It also enhanced the neuronal differentiation of adult NSCs and their ability to migrate. These results provide us with valuable information regarding the effects of Aβ 42 on NSCs in the brains of patients with AD.
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