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Calcium/Calmodulin‐Stimulated Protein Kinase II Is Present in Primary Cultures of Cerebral Endothelial Cells
Author(s) -
Deli Mária A.,
Joó Ferenc,
Krizbai István,
Lengyel Imre,
Nunzi Maria G.,
Wolff Joachim R.
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb13429.x
Subject(s) - microbiology and biotechnology , postsynaptic potential , calmodulin , calcium , biology , phosphorylation , protein kinase a , calcium signaling , kinase , calcium in biology , long term potentiation , protein kinase c , receptor , biochemistry , intracellular , chemistry , enzyme , organic chemistry
Abstract: Calcium/calmodulin‐stimulated protein kinase II (CaMPK II). a major kinase in brain, has been established to play an important role in neurotransmitter release and organization of postsynaptic receptors, and it is known to be involved in long‐term potentiation and memory. Less is known about the function of this enzyme in nonneural cells. Here we report on the production, presence, and phosphorylation of the α‐subunit of CaM‐PK II in primary cultures of cerebral endothelial cells. These results raise the possibility that α‐CaM‐PK II can act as one of the key enzymes of calcium‐mediated intracellular signaling in the cerebral endothelial cells and suggest that α‐CaM‐PK II may participate in such basic cellular processes as permeability in physiological and pathological conditions.