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Expression of the Ganglioside GD3 in Human Meningiomas Is Associated with Monosomy of Chromosome 22
Author(s) -
Fredman P.,
Dumanski J.,
Davidsson P.,
Svennerholm L.,
Collins V. P.
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb05765.x
Subject(s) - ganglioside , monosomy , sialic acid , biology , chromosome , microbiology and biotechnology , genetics , karyotype , gene
Abstract: The ganglioside composition of 59 meningiomas has been compared with a molecular genetic analysis of chromosome 22 in the same specimens. Major gangliosides were GM3 (II 3 NeuAc‐LacCer) and/orGD3 [II 3 (NeuAc) 2 ‐LacCer]. In specimens with no or partial deletions of chromosome 22, the GM3 ganglioside predominated, and the mean value for GM3, 61% of total sialic acid, was around four times higher than that for GD3. A loss of chromosome 22, found in 56% of the specimens, was shown to be associated with an increase in the proportion of ganglioside GD3, with the ratio between mean values of GM3 and GD3 being ∼ 1:1. Logistic regression revealed that the probability of predicting monosomy of chromosome 22 by the GD3 proportion was 66%.