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Effect of Latent Iron Deficiency on 5‐Hydroxytryptamine Metabolism in Rat Brain
Author(s) -
Shukla Arti,
Agarwal K. N.,
Chansuria J. P. N.,
Taneja V.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb02515.x
Subject(s) - monoamine oxidase , medicine , endocrinology , tryptophan , iron deficiency , chemistry , metabolism , hemoglobin , serotonin , biochemistry , biology , enzyme , amino acid , anemia , receptor
Abstract: Eight weeks of latent iron deficiency in weaned rats maintained on an experimental low iron content diet (18–20 mg/kg) did not significantly alter the packed cell volume and hemoglobin concentration; however, the hepatic and brain nonheme iron contents decreased by 66% and 21% (p < 0.001), respectively. The tryptophan concentration decreased by 31% and 34% in liver and brain, respectively, in rats on experimental diet (p < 0.01). The brain 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid contents were reduced by 21% and 23% (p < 0.01 and p < 0.02), respectively. However, in the brain, weight, protein, DNA, and the activities of monoamine oxidase, aldehyde dehydrogenase, and liver tryptophan oxygenase were found to remain unaltered. When rehabilitated with a diet containing 390 mg/kg iron, rats previously maintained on the experimental diet for 2 weeks showed partial recovery in tryptophan levels both in liver and brain. However, brain 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid levels remained unaltered. The hepatic iron content improved without any change in brain iron content. The latent iron deficiency produced significant alterations in the metabolism of 5‐hydroxytryptamine and brain iron content that could not be recovered 2 weeks after the iron rehabilitation.