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Regional Distribution of Calmodulin Activity in Rat Brain
Author(s) -
Zhou LW.,
Moyer J. A.,
Muth E. A.,
Clark B.,
Palkovits M.,
Weiss B.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb08809.x
Subject(s) - calmodulin , cerebrum , cerebellum , pons , hypothalamus , midbrain , distribution (mathematics) , biology , neuroscience , medulla , phosphodiesterase , medulla oblongata , endocrinology , medicine , central nervous system , chemistry , biochemistry , enzyme , mathematical analysis , mathematics
Calmodulin activity in 68 discrete areas of rat brain, obtained by micropunch technique, was assessed by its capacity to activate a calmodulin‐sensitive form of phosphodiesterase. In general, the activity of calmodulin was higher in the telencephalon, limbic system, and hypothalamus than in the mesencephalon, pons, cerebellum, and medulla. However, there were substantial differences in calmodulin activity in discrete nuclei of each region. The regional distribution of calmodulin activity in rat brain does not appear to correlate with that of any of the known putative neurotransmitters or peptides.