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Demonstration and Distribution of Kassinin‐Like Material (Substance K) in the Rat Central Nervous System
Author(s) -
Shults C. W.,
Yajima H.,
Gullner H.G.,
Chase T. N.,
O'Donohue T. L.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb04023.x
Subject(s) - eledoisin , substance p , neurokinin b , medicine , endocrinology , chemistry , neurokinin a , distribution (mathematics) , biology , neuropeptide , receptor , mathematical analysis , mathematics
Antiserum was raised against kassinin in rabbits. Cross‐reactivity with other tachykinins was determined; these included substance K (100%) and substance P (0.1%). Peptides extracted from rat brain and synthetic tachykinins were chromatographed by reverse‐phase HPLC. The major peak of kassinin‐like material eluted at a time different from that of synthetic kassinin, eledoisin, physalaemin, neurokinin β, and substance P but coeluted with substance K. Measurement of kassinin‐like material in macrodissected and microdissected brain regions indicated that the distribution of kassinin‐like material was similar to that of substance P.