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Alternative Pathways of Glucose Utilization in Brain: Changes in the Pattern of Glucose Utilization and of the Response of the Pentose Phosphate Pathway to 5‐Hydroxytryptamine During Aging
Author(s) -
Zubairu Salmata,
Hothersall John S.,
ElHassan Asia,
McLean P.,
Greenbaum A. Leslie
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb11816.x
Subject(s) - pentose phosphate pathway , pentose , carbohydrate metabolism , biochemistry , biology , glucose uptake , chemistry , glycolysis , microbiology and biotechnology , metabolism , insulin , fermentation
Abstract: The oxidation of differentially labelled glucose, pyruvate and glutamate in brain slices from rats aged 20 days to 26 months has been studied and the partition of the glucose used into the glycolytic‐tricarboxylic acid cycle pathway, the pentose phosphate pathway and the glutamate‐GABA shunt has been calculated. Over the time range 4 to 26 months, there is an approximately 20% decrease in the production of CO 2 via the glycolytic‐tricarboxylic acid cycle route, as there is in the rate of glucose phosphorylation. The glutamate‐GABA pathway falls by about 50% over this same time span. The broad activity of the pentose phosphate pathway falls rapidly and cannot be detected in the brains of rats aged 18 months or more, whereas the fully stimulated pathway, i.e. in the presence of the artificial electron acceptor phen‐azine methosulphate, declines only marginally over this period, falling sharply only after 23 months. The pentose phosphate pathway is stimulated by the presence of 5‐hy‐droxytryptamine and this stimulation appears to increase with age.