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Subcellular Localization of Bioactive Cholecystokinin‐Like Peptides in the Rat Cerebral Cortex
Author(s) -
Varró Andrea,
Lonovics J.,
Hajnal F.,
Somogyi J.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb04824.x
Subject(s) - cholecystokinin , synaptic vesicle , cerebral cortex , synaptosome , acetylcholine , synaptic membrane , chemistry , distribution (mathematics) , vesicle , biophysics , cortex (anatomy) , neuroscience , biochemistry , biology , membrane , endocrinology , receptor , mathematical analysis , mathematics
The subcellular distribution of cholecystokinin (CCK), especially its exact localization within the synaptosome, was studied in the rat cerebral cortex. Highest CCK‐like bioactivity was measured in the synaptic membrane fractions, paralleling the distribution of (Na + + K + )‐dependent ATPase. In the synaptic vesicles, which were characterized by high acetylcholine content and by the absence of (Na + + K + )‐ATPase, only minimal quantities of CCK were detected.