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Increased Levels of Neuron‐Specific Enolase in PC 12 Pheochromocytoma Cells as a Result of Nerve Growth Factor Treatment
Author(s) -
Vinores S. A.,
Marangos P. J.,
Parma A. M.,
Guroff G.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12528.x
Subject(s) - enolase , nerve growth factor , pheochromocytoma , neuron , chemistry , medicine , endocrinology , microbiology and biotechnology , biology , neuroscience , cancer research , immunohistochemistry , receptor
Abstract: Treatment of PC 12 pheochromocytoma cells with nerve growth factor (NGF) resulted in increased levels of neuron‐specific enolase (NSE). Neither insulin, growth hormone, cytochrome c , nor sodium butyrate increased NSE levels. Epidermal growth factor (EGF) did increase NSE levels, although not to the same extent as NGF. As little as 1 ng/ml NGF induced the maximal increase in NSE. As PC 12 cells increased in density, the NSE levels increased even in untreated cells.