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Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant Drugs
Author(s) -
Janowsky Aaron,
Steranka Larry R.,
Gillespie David D.,
Sulser Fridolin
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb04739.x
Subject(s) - antidepressant , neuroscience , function (biology) , receptor , signal (programming language) , pharmacology , biology , chemistry , microbiology and biotechnology , computer science , hippocampus , biochemistry , programming language
Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.