Regional Distribution and Production Rate of 3‐Methoxy‐4‐Hydroxyphenylethyleneglycol Sulphate (MHPG‐SO 4 ) in Rat Brain | Zendy

Kohno Yasuko | Zendy; Tanaka Masatoshi | Zendy; Nakagawa Ryoichi | Zendy; Toshima Nobuo | Zendy; Nagasaki Nobuyuki | Zendy

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Regional Distribution and Production Rate of 3‐Methoxy‐4‐Hydroxyphenylethyleneglycol Sulphate (MHPG‐SO 4 ) in Rat Brain

Author(s) -

Kohno Yasuko,

Tanaka Masatoshi,

Nakagawa Ryoichi,

Toshima Nobuo,

Nagasaki Nobuyuki

Publication year - 1981

Publication title -

journal of neurochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.75

H-Index - 229

eISSN - 1471-4159

pISSN - 0022-3042

DOI - 10.1111/j.1471-4159.1981.tb02405.x

Subject(s) - probenecid , distribution (mathematics) , medicine , endocrinology , turnover , chemistry , production rate , biology , industrial engineering , mathematical analysis , mathematics , management , engineering , economics

The levels of noradrenaline (NA) and 3‐methoxy‐4‐hydroxyphen‐ylethyleneglycol sulphate (MHPG‐SO 4 ) in 15 brain regions showed a parallel distribution in male Wistar rats. The differences in regional distribution of MHPG‐SO 4 were similar to those in the rate of NA turnover reported by other investigators. The accumulation rates of MHPG‐SO 4 during 45 and 90 min after probenecid injection significantly correlated to the steady state levels of MHPG‐SO 4 in nine regions studied. With the results, the regional levels of MHPG‐SO, either in untreated or in probenecid‐treated rats, are considered to be a useful index of NA turnover.

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