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Circadian Variation of Cyclic AMP in the Rat Pineal Gland
Author(s) -
Mikuni Masahiko,
Saito Yoshiro,
Koyama Tsukasa,
Yamashita Itaru
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01733.x
Subject(s) - circadian rhythm , endocrinology , medicine , pineal gland , propranolol , biology , chemistry
This study was carried out to investigate circadian variation of cyclic AMP contents in the rat pineal glands, using the high‐energy microwave radiation technique. The pattern of cyclic AMP concentration in the pineal gland showed a distinct circadian variation, with the maximum level at 0200 and the lowest at 1400. The administration of propranolol completely blocked the dark‐induced increase in the pineal cyclic AMP level at 0200, and the administration of isoproterenol induced a threefold, rapid increase in the cyclic AMP level at 1400, although it did not change the level at 0200.