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Effect of Estrogen on Denervated Muscle
Author(s) -
Max Stephen R.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01702.x
Subject(s) - medicine , endocrinology , denervation , estrogen , biology , choline acetyltransferase , hypophysectomy , hormone , chemistry , acetylcholine
The rate of increase of glucose 6‐phosphate dehydrogenase activity in denervated rat extensor digitorum longus muscle shows sexual dimorphism. This phenomenon is further investigated in this report by assessing the effects of ovariectomy, hypophysectomy, hormone replacement therapy, and treatment with an estrogen antagonist, MER‐25. The data demonstrate that physiologic doses of estrogens enhance the rate and extent of the increase in glucose 6‐phosphate dehydrogenase activity after denervation. The data further indicate that aromatization of androgens may be a significant source of estrogen involved in hormonal modulation of the neural control of glucose 6‐phosphate dehydrogenase and other processes in muscle. Furthermore, choline acetyltransferase activity, a marker for the neuromuscular synapse, decreased in rat extensor digitorum longus muscles after denervation, but was unaffected by ovariectomy.