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BRAIN CONCENTRATIONS OF BIOGENIC AMINES AND THEIR METABOLITES IN TWO TYPES OF PYROGEN‐INDUCED FEVER IN RABBITS
Author(s) -
GardeyLevassort Christiane,
Tanguy Odette,
Lechat P.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb07724.x
Subject(s) - lipopolysaccharide , biogenic amine , dopamine , chemistry , amine gas treating , norepinephrine , endocrinology , medicine , metabolite , serotonin , biology , biochemistry , receptor , organic chemistry
Abstract— The effects of two bacterial pyrogens (gonococcus vaccine and E. coli lipopolysaccharide) on brain and CSF concentrations of the biogenic amines and their major metabolites were compared in rabbits. Both pyrogens induced a similar fever, but only the lipopolysaccharide elicited marked biochemical alterations. The main changes observed were: a decrease in the concentrations of acid metabolites of dopamine during the upward course of the first peak of fever; a decrease in the hypothalamic concentrations of noradrenaline at the second peak of fever; a general increase in the metabolites of biogenic amines around the second peak and during the fall of fever. The results led to the conclusion that no significant correlation exists between body temperature and brain amine levels in rabbits. The alterations observed could be a consequence of the fever itself when considered in terms of trauma to the organism.