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Changes of plasma vascular endothelial growth factor level after uterine artery embolisation for leiomyomata
Author(s) -
Takeda Takashi,
Osuga Keigo,
Morishige Kenichirou,
Tasaka Keiichi,
Nakamura Hironobu,
Murata Yuji
Publication year - 2005
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2005.00690.x
Subject(s) - medicine , uterine artery , vascular endothelial growth factor , vegf receptors , artery , plasma levels , gynecology , biology , pregnancy , genetics , gestation
Uterine artery embolisation (UAE) has become an alternative treatment for symptomatic uterine leiomyomata. Most reports suggest that it is well tolerated and effective, although there have been no reports of studies of biological parameters after UAE. In this study, we analysed the plasma level of vascular endothelial growth factor (VEGF) and the pulsatility index (PI) of uterine arteries before and after UAE. The level of plasma VEGF increased significantly after UAE (on day 1 and day 3) and decreased on day 7, and then increased again on day 30. The level of VEGF reached a peak value within three days after UAE. A significant inverse correlation was found between uterine artery PI and the level of VEGF on day 30, suggesting that VEGF may have negative effect on the efficacy of treatment of uterine leiomyomata by UAE.