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Platelet reactivity and serum thromboxane B 2 production in whole blood in gestational hypertension and pre‐eclampsia
Author(s) -
LOUDEN K. A.,
PIPKIN F. BROUGHTON,
HEPTINSTALL S.,
FOX S. C.,
MITCHELL J. R. A.,
SYMONDS E. M.
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb15396.x
Subject(s) - eclampsia , platelet , context (archaeology) , thromboxane b2 , gestational hypertension , preeclampsia , gestation , medicine , endocrinology , thromboxane , platelet activation , thromboxane a2 , pregnancy , obstetrics , biology , paleontology , genetics
Objective— To determine the nature and extent of changes in platelet reactivity in gestational hypertension and pre‐eclampsia (using whole blood techniques which may be more physiological than those previously employed). Design— Cross‐sectional observational study. Subjects— 8 normal primigravidae, 16 women with gestational hypertension and 12 women with pre‐eclampsia, studied at around 36 weeks gestation. Results— Platelet reactivity (aggregation and release reaction) induced by stimulation with adrenaline was decreased in the pre‐eclamptic group. Serum thromboxane B 2 production was unchanged in both hypertensive groups compared with the control group. Conclusions— In the context of evidence of platelet activation in pre‐eclampsia, our findings are interpreted as reflecting platelet exhaustion.
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