Premium
The disappearance rate of Schwangerschaftsprotein 1 in normal and pathological pregnancies
Author(s) -
HUTTENMOSER J. L.,
WEILFRANCK C.,
BISCHOF P.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb03119.x
Subject(s) - curettage , pregnancy , gestation , obstetrics , medicine , gynecology , ectopic pregnancy , radioimmunoassay , vaginal delivery , first trimester , pathological , endocrinology , surgery , biology , genetics
Summary In six women with a normal vaginal delivery at term, in 12 women who had a suction curettage between 6 and 12 weeks gestation and in eight women with an ectopic pregnancy, the post‐partum or the post‐surgery decline in radioimmunoassayable SP1 was faster during the first 24 h after surgery or delivery than later, so that two half‐lives were calculated. The first‘half‐life’of about 20 h (0–24 h after delivery or surgery) was of the same order of magnitude in all groups studied and corresponded well to previously published values. The mean second‘half‐life’(<24 h after delivery or surgery) was significantly longer in term (72·2 h) and in ectopic pregnancies (64·1 h) than in first trimester pregnancies (45·5 h). These results might indicate that the metabolism of SP1 either changes during pregnancy or that the changing SPl β /SPl α ratio during pregnancy markedly influences the levels of SP1 as measured by radioimmunoassay.