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Abnormal concentrations of prostaglandins in amniotic fluid during delayed labour in multigravid patients
Author(s) -
REDDI K.,
KAMBARAN S. R.,
NORMAN R. J.,
JOUBERT S. M.,
PHILPOTT R. H.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb04850.x
Subject(s) - cervical dilatation , radioimmunoassay , prostaglandin , amniotic fluid , medicine , endocrinology , thromboxane , thromboxane a2 , chemistry , pregnancy , fetus , biology , cervix , platelet , cancer , genetics
Summary. Concentrations of prostaglandins E (PGE), F 2α (PGF), 13,14‐dihydro‐15‐keto prostaglandin F 2α (PGFM), 6‐keto F 1α and thromboxane B 2 were measured by specific radioimmunoassay in samples of amniotic fluid from 22 multigravid patients during labour. Normal labour in 10 patients was associated with a significant increase of PGE, PGF and PGFM with close correlation to cervical dilatation ( P < 0.05). In the 12 patients with clinically delayed labour, in the absence of cephalopelvic disproportion, there were significantly lower PGF ( P <0.002) and PGFM ( P < 0.05) concentrations obtained while no differences were observed in the other prostanoids measured. Administration of oxytocin to the latter group to enhance labour did not have any effect on the concentrations of prostaglandins obtained in spite of an improvement in intrauterine pressures and accelerated progress of labour.