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MEASUREMENT OF THE LECITHIN/SPHINGOMYELIN RATIO AND PHOSPHATIDYLGLYCEROL IN AMNIOTIC FLUID: AN ACCURATE METHOD FOR THE ASSESSMENT OF FETAL LUNG MATURITY
Author(s) -
Hallman Mikko,
Teramo Kari
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb01307.x
Subject(s) - phosphatidylglycerol , amniotic fluid , lecithin , sphingomyelin , phospholipid , chromatography , fetus , chemistry , medicine , biology , cholesterol , pregnancy , biochemistry , membrane , phosphatidylcholine , genetics
Summary A total of 506 amniotic fluid samples from 337 pregnancies was analysed for lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol. Two‐dimensional chromatography on either laboratory‐made or commercial thin‐layer silica gel plates was required for proper resolution of the phospholipids. The predictive accuracy of the L/S ratio and the phosphatidylglycerol analysis was assessed in 225 patients, 187 of whom had an L/S ratio of 2 or more. In addition to predicting respiratory distress syndrome of the newborn, the phospholipid results predicted the risk of transient tachypnoea, symptomatic pneumothorax and the persistence of fetal circulation. The phosphatidylglycerol results improved the predictive value of both the mature L/S ratio (2 or more) and the non‐mature L/S ratio (below 2).