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FERTILITY IN WOMEN WITH TURNERS SYNDROME CASE REPORT AND REVIEW OF LITERATURE
Author(s) -
Nielsen J.,
Sillesen Ingelise,
Hansen K. B.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10706.x
Subject(s) - turner syndrome , karyotype , amniocentesis , abortion , pregnancy , medicine , abnormality , gynecology , chromosomal abnormality , obstetrics , incidence (geometry) , fertility , down syndrome , chromosome abnormality , fetus , pediatrics , chromosome , prenatal diagnosis , biology , genetics , psychiatry , population , physics , environmental health , gene , optics
Summary A successful pregnancy in a woman with Turner's syndrome with a 45, X/46,XX karyotype is described. The literature contains reports of a total of nine pregnancies in seven women with a 45,X karyotype and 56 pregnancies in 23 women with mosaicism and a 45,X cell line, as well as a 46,XX and/or 47,XXX cell line. Fifteen of the latter 56 pregnancies ended in spontaneous abortion (27 per cent), and four ended in the delivery of a stillborn child; 12 of the 37 liveborn infants (32 per cent) had a physical or mental abnormality, and 8 (22 per cent) had a chromosome abnormality. Three had Down's syndrome, and five had a 45,X cell line. Due to the relatively high (8 per cent) incidence of Down's syndrome among liveborn infants of women with Turner's syndrome, amniocentesis for fetal karyotyping should be advised.