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Activity of adenosine deaminase allelic forms in intact erythrocytes and in lymphocytes
Author(s) -
BATTISTUZZI G.,
IUDICONE P.,
SANTOLAMAZZA P.,
PETRUCCI R.
Publication year - 1981
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1981.tb00301.x
Subject(s) - adenosine deaminase , allele , adenosine deaminase deficiency , biology , amp deaminase , genetics , adenosine , gene , biochemistry
SUMMARY The distribution of ADA activity has been studied for ADA 1 and ADA 2‐1 individuals in intact and lysed erythrocytes and in lymphocyte lysates. ADA activity in intact RBC is 20‐30% lower than in lysates, in lymphocytes it is 10 times higher. The difference between ADA 1 and ADA 2‐1 mean enzyme activities which we previously described in RBC lysates has been found also in intact RBC and in lymphocyte lysates.