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Racial variations in the incidence of congenital malformations
Author(s) -
ERICKSON J. DAVID
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00135.x
Subject(s) - proband , incidence (geometry) , congenital malformations , demography , medicine , pediatrics , genetics , biology , mutation , pregnancy , physics , sociology , gene , optics
Summary Racial variation in the incidence of several common congenital malformations has been studied in Atlanta, Georgia. The white‐to‐black incidence ratios were substantially different from unity for single defects, while approximate equality of rates was noted for multiple defects. Amongst the specific malformations for which familial data were available, affected first‐ and second‐degree relatives were found only in the families of probands with single defects. It is postulated that these findings may indicate a more prominent function of the environment in the genesis of multiple malformations than is the case for single defects, the occurrence of which may be more strongly affected by non‐sporadic genetic factors.