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Review of the potential photo‐cocarcinogenicity of topical calcineurin inhibitors
Author(s) -
Ring J,
Barker J,
Behrendt H,
Braathen L,
Darsow U,
Dubertret L,
Giannetti A,
Hawk J,
Hönigsmann H,
Kemeny L,
Luger T,
Meurer M,
Murphy G,
Peserico A,
Ranki A,
Reunala T,
Saurat J,
Sterry W,
Kerkhof P
Publication year - 2005
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2005.01315.x
Subject(s) - medicine , calcineurin , dermatology , skin cancer , cancer , transplantation
ABSTRACT Topical Calcineurin Inhibitors (TCIs) used for the treatment of atopic eczema modify the immune regulatory function of the skin and may have the potential to enhance immunosuppressive ultraviolet (UV) effects. Current recommendations on UV protection in eczema patients treated with PCIs are inconsistent and have given rise to uncertainty and anxiety in patients. Therefore, the European Dermatology Forum (EDF) developed a position statement which reviews critically the available data with regard to the problem, especially analysing and commenting the limitations of rodent models for the human situation. There is no conclusive evidence from rodent trials to indicate that long‐term application of TCIs is photococarcinogenic. There is a need for further studies to investigate the validity of mouse models as well as long‐term cohort studies in patients using TCIs. Available data suggest that long‐term application of TCIs is safe, that there is no evidence of increased skin cancer risk and that it is ethical to treat patients with TCIs when indicated.