Premium
Response adaptive procedures with dual optimality
Author(s) -
Bandyopadhyay Uttam,
Bhattacharya Rahul
Publication year - 2009
Publication title -
statistica neerlandica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.52
H-Index - 39
eISSN - 1467-9574
pISSN - 0039-0402
DOI - 10.1111/j.1467-9574.2009.00428.x
Subject(s) - sketch , dual (grammatical number) , computer science , extension (predicate logic) , class (philosophy) , mathematical optimization , adaptive strategies , mathematics , machine learning , algorithm , artificial intelligence , art , literature , archaeology , history , programming language
The paper proposes an optimal response‐adaptive procedure for a general class of responses using a combination of two clinically relevant optimality criteria. We provide a thorough development for trials involving two treatments and sketch the possible extension for multiple treatments. Some related asymptotic results are worked out. We provide simulation studies to compare the performance of the proposed procedure with some of the existing competitors. We illustrate our methodology on data from a real clinical trial.