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A new model for the assay of comedolytic activity
Author(s) -
BONNE CLAUDE,
ZEZIOLA FRANCE,
SECCHI JEAN,
SAURAT JEANHICLAIRE
Publication year - 1981
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1981.tb00264.x
Subject(s) - comedo , animal model , nuclear medicine , microbiology and biotechnology , biology , medicine , cancer , breast cancer , ductal carcinoma
Synopsis An experimental model using the ‘Rhino’ hairless mouse has been developed for screening comedolytic agents. The skin of this animal presents a high density of spontaneous comedos which appear in histological slices as cystic formations with a large diameter (D) and an open narrow neck (d). The ratio d/D expresses the ‘comedo profile'. Statistical evaluation of this value by standardized measurement allows the quantification of comedolytic activity of pharmacological agents. Un nouveau modèle pour la mesure de l'activité comédolytique
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