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A Chinese Family with Non‐insulin‐dependent Diabetes of Early Onset and Severe Diabetic Complications
Author(s) -
Chan J.C.N.,
Hawkins B.R.,
Cockram C.S.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01372.x
Subject(s) - medicine , diabetes mellitus , insulin , inheritance (genetic algorithm) , age of onset , insulin dependent diabetes , presentation (obstetrics) , family history , pediatrics , endocrinology , disease , surgery , autoimmune disease , genetics , gene , biology
Non‐insulin‐dependent diabetes mellitus of early onset has recently been described in Caucasians as a distinct syndrome with a characteristic pedigree suggestive of inheritance of genetic determinants from both parents. It is characterized by absence of islet cell antibodies and the severity of its clinical course. We report a Chinese family pedigree of three generations in which this form of diabetes has affected the third generation. Some members of this pedigree had severe complications at presentation in their twenties.