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The beneficial effect of alfuzosin 10 mg once daily in ‘real‐life’ practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation
Author(s) -
NICKEL J. CURTIS,
ELHILALI MOSTAFA,
EMBERTON MARK,
VALLANCIEN GUY
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.06171.x
Subject(s) - alfuzosin , lower urinary tract symptoms , medicine , tamsulosin , ejaculation , urology , sexual dysfunction , erectile dysfunction , international prostate symptom score , prostatitis , quality of life (healthcare) , premature ejaculation , sexual function , population , prostate , psychology , nursing , environmental health , cancer , hyperplasia , psychoanalysis
OBJECTIVE To determine the efficacy and safety of the selective α 1 ‐blocker alfuzosin in men with lower urinary tract symptoms (LUTS) and painful ejaculation, compared with those with LUTS only, as painful ejaculation is one of the most prevalent, differentiating and bothersome symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. PATIENTS AND METHODS In all, 4857 sexually active men with LUTS had an evaluable answer to the Danish Prostate Symptom Score for Sexual Symptoms question related to pain/discomfort on ejaculation at enrolment in a 6‐month open‐label study with alfuzosin 10 mg once daily. Efficacy was analysed at the endpoint in the intent‐to‐treat population. RESULTS Of the 4857 men, 997 (20.5%) had pain/discomfort on ejaculation and 889/997 (89.2%) considered it was a problem. At inclusion, men with painful ejaculation had more severe LUTS and bother than men with LUTS only. Erectile dysfunction (ED) and reduced ejaculation were more prevalent (74.5% and 71.9%, respectively) and bothersome in men with painful ejaculation than in those with no pain (59.6% and 57.4%, respectively). Under alfuzosin treatment, all variables in both groups significantly improved from baseline; men with painful ejaculation compared to LUTS‐only had similar improvements in weighted scores for LUTS (−7.8 vs −7.7), bother (−1.7 vs −1.7), and reduced ejaculate (−0.5 vs −0.4) but greater improvements in ED (−0.6 vs −0.4; P < 0.001). The weighted score for painful ejaculation decreased from 2.2 to 0.8 ( P < 0.001). Alfuzosin was well tolerated in both groups. CONCLUSIONS This 6‐month open‐label study suggests that alfuzosin 10 mg once daily significantly improves LUTS, quality of life and sexual function in men with prostatitis‐like symptoms, and is well tolerated.