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Eicosanoid Synthesis by Human Urinary Bladder Mucosa: Pathological Implications
Author(s) -
JEREMY J. Y.,
TSANG V.,
MIKHAILIDIS D. P.,
ROGERS H.,
MORGAN R. J.,
DANDONA P.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04575.x
Subject(s) - prostacyclin , eicosanoid , urinary bladder , thromboxane , prostaglandin , urinary system , thromboxane a2 , cystoscopy , medicine , endocrinology , prostanoid , contractility , lipoxin , prostaglandin e , thromboxane b2 , chemistry , platelet , inflammation , arachidonic acid , biochemistry , enzyme
Summary— Biopsies of human urinary bladder mucosa obtained during cystoscopy were shown to release eicosanoids in the following order: prostacyclin (PGI 2 ), prostaglandin E 2 (PGE 2 ), prostaglandin F 2x (PGF 2x ) and thromboxane A 2 (TXA 2 ). The total and the relative amounts of eicosanoids released were similar to those reported for the rat urinary bladder. These eicosanoids may play a role in modulating the tone and contractility of the bladder as well as affecting cytoprotection of the mucosa. In view of the abundant release of eicosanoids by the bladder, caution must be exercised when considering urinary eicosanoid excretion as reflecting production by the systemic vasculature and/or the kidneys.
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