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The Management of Disseminated Testicular Cancer
Author(s) -
RAMSEY E. W.,
BOWMAN D. M.,
WEINERMAN B.
Publication year - 1980
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1980.tb02918.x
Subject(s) - bleomycin , vinblastine , medicine , complete remission , testicular cancer , surgery , metastasis , disease , cancer , toxicity , chemotherapy , gastroenterology
Summary— Fourteen patients with disseminated non‐seminomatous germ cell tumours of the testis were treated with a 3‐drug combination of vinblastine, bleomycin and cis‐diamminedichloroplatinum. Of 13 patients with measurable disease, 9 (9%) had complete and 3 (23%) partial remission. One patient with a solitary metastasis failed to respond but is disease–free following surgical excision. Toxicity was significant but no drug‐related deaths occurred and there were no apparent lasting side effects. No patient attaining complete remission has relapsed. Eleven (79%) of the 14 patients are without evidence of disease from 3+ to 36+ months, 6 of these for 2 years or more. Of the patients in partial remission one died at 16 months and one is undergoing further treatment for relapse with liver metastases. One patient remains in partial remission at 30 months. These results demonstrate the efficacy of this drug combination in testicular cancer.